The Use of Polydeoxyribonucleotide in Dentistry: A Scoping Review
Yong-Shin Hong and Young-Seok Park
Current Views in Dentistry. 2026;1:001.
Article type:
Scoping Review
Published:
2026
DOI:
To be assigned
ISSN:
To be assigned
Keywords:
Polydeoxyribonucleotide; Polynucleotide; Dentistry; Regeneration; Scoping review
Abstract:
Objectives
This scoping review aimed to map the current evidence on polydeoxyribonucleotide (PDRN) and related polynucleotide-based materials in dentistry, oral medicine, periodontology, implant dentistry, oral and maxillofacial surgery, temporomandibular disorders, and oral tissue regeneration.
Methods
A scoping review was conducted following established methodological frameworks and PRISMA-ScR principles. PubMed/MEDLINE and Embase were searched for studies evaluating PDRN, polynucleotides, PN-HA formulations, sodium-DNA preparations, salmon DNA-derived materials, or related nucleotide-based biomaterials in dental and oral-maxillofacial contexts. Clinical, preclinical, nonclinical, and supportive review-level evidence were mapped according to study type, indication, material formulation, delivery method, and outcome domain.
Results
The final evidence map included 49 articles: 13 clinical studies, 30 preclinical or nonclinical studies, and 6 supportive review or commentary articles. PDRN and related materials were investigated across bone regeneration, alveolar ridge preservation, sinus augmentation, implant-related hard- and soft-tissue regeneration, periodontal and mucogingival therapy, oral mucosal repair, MRONJ/BRONJ-related models, temporomandibular disorders, and postoperative morbidity after third molar surgery. Preclinical studies provided biological plausibility through anti-inflammatory, pro-angiogenic, pro-healing, and osteogenic effects. Clinical evidence was most consistent for short-term reduction of postoperative inflammatory morbidity, whereas evidence for periodontal, bone-regenerative, TMJ, and mucosal applications remained limited or heterogeneous.
Conclusions
PDRN and related polynucleotide-based materials show promise as locally delivered adjunctive agents in dental and oral-maxillofacial applications. However, current evidence remains heterogeneous and insufficient to establish them as stand-alone dental therapeutics. Future studies should adopt standardized material reporting, appropriate comparator groups, longer follow-up, and indication-specific controlled clinical trial designs
How to cite:
Hong YS, Park YS. The use of polydeoxyribonucleotide in dentistry: A scoping review. Current Views in Dentistry. 2026;1:001.